Germline - Immortality Through Totipotency
European Molecular Biology Laboratory Heidelberg, Germany
Saturday 13 October - Tuesday 16 October 2012
Why You Should Attend
Summary
What does immortality mean at the molecular, cellular, transgenerational and evolutionary level?
Most organisms have a defined lifespan, however life of a species continues and evolves via germline from generation to generation. Recent studies show that tissue stem cells share molecular and developmental signatures with the germline and that even fully differentiated, postmitotic cells can be reprogrammed to regain totipotency.
This EMBO | EMBL Symposium will go beyond a description of the phenomena involving stem cell behaviour, programming and reprogramming. It will bring together researchers from different disciplines, who will address fundamental questions of totipotency as they relate to evolution, development and tissue specialization.
Questions to be discussed include:
how a need for germline specification arose during the evolution of multicellularity from single cells to colonies with specialized cell types;
how the fertilized egg cell loses totipotency during formation of a multicelluar organism;
how chromatin-based mechanisms influence totipotency both at the cellular and transgenerational level; and
how the decision toward meiosis is achieved and regulated.
Topics
From single cells to multicellularity
Keeping it all together: chromosomes and chromatin
Programming and reprogramming
Conservative vs progressive divisions (mitosis and meiosis)
Context matters
EMBL Course and Conference Office
European Molecular Biology Laboratory
Meyerhofstraße 1
69117 Heidelberg
Germany
Tel: +49 6221 387 8797
Fax: +49 6221 387 8158