6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation – The CHIC Project Workshop
3-4 November 2014 Athens, Greece
In silico medicine, an emergent scientific and technological domain based on clinically driven and oriented multiscale biomodeling, appears to be the latest trend regarding the translation of mathematical and computational biological science to clinical practice through massive exploitation of information technology. The term multiscale refers to several scales or levels of the manifestation of life such as the molecular, the cellular, the tissue, the organ, and the body system scales addressed concurrently.
The overarching idea is to view disease as a hypercomplex and multiscale natural phenomenon amenable to modeling and simulation. In silico (i.e., on the computer) experimentation for each individual patient using their own multiscale biomedical data is expected to significantly improve the effectiveness of treatment in the future, since reliable computer predictions could suggest the optimal treatment scheme(s) and schedules(s) for each separate case.
Clinically driven complex multiscale cancer models can produce realistic spatio-temporal simulations of concrete clinical interventions such as radio-chemotherapy applied to individual patients.
Clinical data processing procedures and computer technologies play an important role in this context. Following clinical adaptation and validation within the framework of clinico-genomic trials, models are expected to enhance individualized treatment optimization. The latter constitutes the long term goal of the emergent scientific, technological and medical discipline of in silico oncology.
Treatment optimization is to be achieved through experimentation in silico. Moreover, provision of insight into tumour dynamics and optimization of clinical trial design and interpretation constitute short- and mid-term goals of this new domain.
The workshop to be held in Athens, Greece is meant to be an excellent opportunity for both shaping and advancing the new discipline.
CHIC stands for Computational Horizons in Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Respositories for In Silico Oncology