Autoimmunity and Tolerance
February 3—8, 2015 Keystone, Colorado
Understanding checkpoints in autoimmunity and immune cell tolerance is important for delivering therapies to patients with uncontrolled autoimmune disease. The goal of this Keystone Symposia meeting on Autoimmunity and Tolerance is to bring together scientists and clinicians to discuss what we are learning from preclinical mouse models and patient studies. The past decade or so has seen the translation of our fundamental understanding of the immune response into clinical studies, with some success and also some failures. These clinical outcomes, coupled with more sophisticated techniques available to interrogate the human immune response, allow us to reassess and further explore pathways that are driving autoimmune disease. In this symposium, we cover the pathways in immunity and tolerance that lead to loss of immunological control, dysregulated immune responses and chronic inflammatory disease. We cover preclinical and clinical aspects of a diverse number of autoimmune and inflammatory diseases including Lupus, Multiple Sclerosis, Inflammatory Bowel Disease, Psoriasis, Transplantation and Rheumatoid Arthritis. Each session is designed to include a basic research talk followed by a mechanistic talk on mouse and human and clinical translation.